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Concise Synthesis of 1??Naphthols under Mild Conditions through a Copper??Catalyzed Arylation of Methyl Ketones

Z Lou, S Zhang, C Chen, X Pang, M Li…

文献索引:Lou, Zhenbang; Zhang, Shu; Chen, Chao; Pang, Xinlong; Li, Ming; Wen, Lirong Advanced Synthesis and Catalysis, 2014 , vol. 356, # 1 p. 153 - 159

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被引用次数: 5

摘要

Abstract: A concise synthesis of 1-naphthols via cyclization of o-iodoacetophenones and methyl ketones has been realized under very mild conditions. The cyclization process is initiated by a rare coppercatalyzed arylation of simple methyl ketones with ortho- iodoacetophenones. Keywords: arylation; copper-catalyzed reaction; ortho- iodoacetophenones; methyl ketones; 1-naphthols