Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose

…, E Zbornikova, A Brezinova, M Pribylova…

文献索引：Dvorakova, Marcela; Nencka, Radim; Dejmek, Milan; Zbornikova, Eva; Brezinova, Anna; Pribylova, Marie; Pohl, Radek; Migaud, Marie E.; Vanek, Tomas Organic and Biomolecular Chemistry, 2013 , vol. 11, # 34 p. 5702 - 5713

全文：HTML全文

被引用次数: 1

摘要

The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.