1, 4, 2-Benzo/pyridodithiazine 1, 1-Dioxides Structurally Related to the ATP-Sensitive Potassium Channel Openers 1, 2, 4-Benzo/pyridothiadiazine 1, 1-Dioxides Exert …

B Pirotte, P De Tullio, X Florence, E Goffin…

文献索引：Pirotte, Bernard; De Tullio, Pascal; Florence, Xavier; Goffin, Eric; Somers, Fabian; Boverie, Stephane; Lebrun, Philippe Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3247 - 3256

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被引用次数: 3

摘要

The synthesis of diversely substituted 3-alkyl/aralkyl/arylamino-1, 4, 2-benzodithiazine 1, 1- dioxides and 3-alkylaminopyrido [4, 3-e]-1, 4, 2-dithiazine 1, 1-dioxides is described. Their biological activities on pancreatic β-cells and on smooth muscle cells were compared to those of the reference ATP-sensitive potassium channel (KATP channel) openers diazoxide and 7-chloro-3-isopropylamino-4 H-1, 2, 4-benzothiadiazine 1, 1-dioxide. The aim was to ...