Bis [[4-(2, 2-dimethyl-1, 3-dioxolyl)] methyl]-carbodiimide (BDDC) and its application to residue-free esterifications, peptide couplings, and dehydrations

FS Gibson, MS Park, H Rapoport

文献索引：Gibson, Frank S.; Park, Myung Sook; Rapoport, Henry Journal of Organic Chemistry, 1994 , vol. 59, # 24 p. 7503 - 7507

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被引用次数: 65

摘要

Carbodiimides are important reagents in synthetic chemistry and are employed in a wide variety of transformations, l generally functioning as dehydrating agents. Carbodiimides such as dicyclohexylcarbodiimide (DCC), diisopropylcarbodiimide (DIC), and 1-(3- (dimethylamino)-propyl)-3-ethylcarbodiimide hydrochloride (EDC) are used primarily as peptide coupling reagents and are employed less frequently for direct 0-acylations. A ...