Helvetica Chimica Acta

A Novel, One??Pot Four??Component Route to 2′??Thioxo??2′, 3′??dihydrospiro [indole??3, 6′??[1, 3] thiazin]??2??one Derivatives

A Alizadeh, J Mokhtari

文献索引：Alizadeh, Abdolali; Mokhtari, Javad Helvetica Chimica Acta, 2011 , vol. 94, # 7 p. 1315 - 1319

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被引用次数: 9

摘要

Abstract An efficient route to 2′, 3′-dihydro-2′-thioxospiro [indole-3, 6′-[1, 3] thiazin]-2 (1H)-one derivatives is described. It involves the reaction of isatine, 1-phenyl-2-(1, 1, 1- triphenyl-λ 5-phosphanylidene) ethan-1-one, and different amines in the presence of CS 2 in dry MeOH at reflux (Scheme 1). The alkyl carbamodithioate, which results from the addition of the amine to CS 2, is added to the α, β-unsaturated ketone, resulting from the reaction ...