Journal of natural products

Biotransformation of polymethoxylated flavonoids: access to their 4'-O-demethylated metabolites

D Buisson, J Quintin, G Lewin

文献索引：Buisson, Didier; Quintin, Jerome; Lewin, Guy Journal of Natural Products, 2007 , vol. 70, # 6 p. 1035 - 1038

全文：HTML全文

被引用次数: 21

摘要

Regioselective O-demethylation of the flavones tangeretin (1) and 3-hydroxytangeretin (6) into their 4'-O-demethylated metabolites was performed by using an Aspergillus niger strain. This method serves as a straightforward alternative to multistep synthesis or semisynthesis. The microbial approach is complementary to the chemical procedure, which furnishes a 5-O- demethylated product. P450 inhibitors prevented the biotransformation of tangeretin (1). ...