On (. of the carly attempts at the development oi mzyme-activated substrates for the much soughtafter selectivity of drug action in cancer chemotherapy rvaa the synthesis of K- phosphorylated nitrogen~ nustards.~ These compounds, which are inactive precursors of cytotoxic mustards, could be activated by phosphamidases; and based on reports of abundance of these enzymes in some tumors it seemed possible for thiq" activation" to ...
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