Antineoplastic agents. XIX. N-Bis (2-haloethyl) glycine amides

GR Pettit, MR Chamberland…

文献索引：Pettit,G.R. et al. Canadian Journal of Chemistry, 1967 , vol. 45, p. 1555 - 1560

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被引用次数: 20

摘要

A number of routes to N-bis (2-fluoroethyl) glycine (III a) were explored. Of these, condensation between N-bis (2-fluoroethyl) amine and bromoacetic acid in tetrahydrofuran proved to be the most satisfactory. Reaction between a carbonic anhydride derivative of, for example, glycine III a and the appropriate aromatic amine provided the glycine amides summarized by structures IV b-IV i. Treatment of N-bis (2-chloroethyl) glycine ...