Journal of medicinal chemistry

Synthesis and biological activity of various 3'-azido and 3'-amino analogs of 5-substituted pyrimidine deoxyribonucleosides

TS Lin, YS Gao, WR Mancini

文献索引：Lin, Tai-Shun; Gao, You-Song; Mancini, William R. Journal of Medicinal Chemistry, 1983 , vol. 26, # 12 p. 1691 - 1696

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被引用次数: 43

摘要

Various new 5-substituted 3'-azido-and 3'-amino derivatives of 2'-deoxyuridine and 2'- deoxycytidine have been synthesized and biologically evaluated. Among these compounds, 3'-amino-2', 3'-dideoxy-5-fluorouridine(3), 3'-amino-2', 3'-dideoxycytidine (7a), and 3 '-amino- 2 ', 3 '-dideoxy-5-fluorocytidine (7c) were found to be the most active against murine L1210 and sarcoma 180 neoplastic cells in vitro, with an ED5o of 15 and 1 pM, 0.7 and 4 pM, and ...