Bicyclic and tricyclic ergoline partial structures. Rigid 3-(2-aminoethyl) pyrroles and 3-and 4-(2-aminoethyl) pyrazoles as dopamine agonists

…, JW Paschal, JA Clemens, EB Smalstig

文献索引：Bach; Kornfeld; Jones; Chaney; Dorman; Paschal; Clemens; Smalstig Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 481 - 491

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被引用次数: 153

摘要

17 11 in which ring D of the ergoline system is lacking, were reported previously by Stoll and Petrzilka13 and by Harris and Uhle. 14 However, an evaluation of the dopamine agonist properties of these compounds has not been available. We prepared this class by a new route, as shown in Scheme I.