Journal of Molecular Catalysis B: Enzymatic

Exploitation of a Candida antarctica lipase B-catalysed in situ carboxylic acid activation method for the synthesis of acetanilides

S Lal, TJ Snape

文献索引：Lal, Samridhi; Snape, Timothy J. Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 83, p. 80 - 86

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被引用次数: 4

摘要

An efficient biocatalytic method has been developed which provides acetanilides in good yields which are otherwise inaccessible using Candida antarctica lipase B. The process exploits the enzyme-catalysed synthesis of an acyl donor and its in situ reaction with anilines. The method is potentially useful for the synthesis of bulky acetanilides since amide formation occurs through an active site-independent step.