Exploring the interaction of N/S compounds with a dicopper center: tyrosinase inhibition and model studies

E Buitrago, A Vuillamy, A Boumendjel, W Yi…

文献索引：Yi, Wei; Cao, Rihui; Chen, Zhiyong; Yu, Liang; Wen, Huan; Yan, Qin; Ma, Lin; Song, Huacan Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 5 p. 752 - 754

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被引用次数: 6

摘要

We report a full description at the enzymatic level of phenylmethylene thiosemicarbazone (PTSC) and phenylthiourea (PTU), as inhibitors of Tyrosinase (Ty). Both compounds exhibit competitive inhibition. With a K IC value of 0.93 μM, PTSC is one of the best mushroom Ty