Tetrahedron

Total synthesis of thienamycin analogs—III: Syntheses of 2-aryl and 2-heteroaryl analogs of thienamycin

LD Cama, KJ Wildonger, R Guthikonda, RW Ratcliffe…

文献索引：Cama; Wildonger; Guthikonda; et al. Tetrahedron, 1983 , vol. 39, # 15 p. 2531 - 2549

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被引用次数: 60

摘要

The total syntheses of 2-aryl and 2-heteroaryl carbapen-2-em-3-carboxylic acids with and without a 6-hydroxyethyl side chain, using a Wittig cyclization for formation of the bicyclic ring system is described. Antibacterial activity of the compounds synthesized is discussed.