New Arylpiperazines with Flexible versus Partly Constrained Linker as Serotonin 5??HT1A/5??HT7 Receptor Ligands

…, J Jaśkowska, B Duszyńska, AJ Bojarski

文献索引：Kowalski, Piotr; Mitka, Katarzyna; Jaskowska, Jolanta; Duszynska, Beata; Bojarski, Andrzej J. Archiv der Pharmazie, 2013 , vol. 346, # 5 p. 339 - 348

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被引用次数: 9

摘要

Abstract A series of new long-chain arylpiperazine (LCAP) derivatives with flexible and partly constrained alkyl linker were synthesized and investigated in vitro as potential serotonin 5-HT 1A and 5-HT 7 receptor ligands. The compounds were prepared by a two- step procedure using naphthalimide and 2H-1, 3-benzoxazine-2, 4 (3H)-dione as imides, and 1-(2-methoxyphenyl) piperazine (o-OMe-PhP) and 1, 2, 3, 4-tetrahydroisoquinoline ( ...