Synthesis of pyrrolizidine alkaloids indicine, intermedine, lycopsamine, and analogs and their N-oxides. Potential antitumor agents

…, JA Glinski, LT Gelbaum, TJ Fleischmann…

文献索引：Zalkow; Glinski; Gelbaum; Fleischmann; McGowan; Gordon Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 687 - 694

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被引用次数: 49

摘要

School of Chemistry, Georgia Institute of Technology, Atlanta, Georgia 30332. Received June 29, 1984 (-)-and (+)-trachelanthic and (-)-and (+)-viridifloric acids were synthesized and their isopropylidene derivatives were regiospecifically coupled, at C-9, wit?(-)- retronecine (2) obtained by hydrqlysis of monocrotaline (I), isolated from Crotalaria spectabilis. Hydrolysis, fouswed by oxidation, led to the N-oxides of indicine (7), ...