Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity

RA Glennon, R Raghupathi, P Bartyzel…

文献索引：Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740

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被引用次数: 113

摘要

Method B. N, N4-Ble (3-azidobutyryl)-l, 4-diaminobutane (16, 239 mg, 0.765 mmol) was added to a 25-mL round-bottom flask followed by attachment of a reflux condenser. THF (5 mL) was added via syringe, dissolving all the solid. BH3. THF solution (1.0 M, 9.18 mL, 9.18 mmol) was slowly added and the resulting mixture was brought to reflux temperature for 24 h. After this time, the mixture was stirred at room temperature for 6 h. An ice bath was used ...