Synthesis, characterization, in vitro anticancer activity, and docking of Schiff bases of 4-amino-1, 2-naphthoquinone

S Shukla, RS Srivastava, SK Shrivastava…

文献索引：Shukla; Srivastava; Shrivastava; Sodhi; Kumar, Pankaj Medicinal Chemistry Research, 2013 , vol. 22, # 4 p. 1604 - 1617

全文：HTML全文

被引用次数: 9

摘要

Abstract A series of Schiff bases of 4-amino-1, 2-naphthoquinone were synthesized, purified, characterized, and evaluated for cytotoxicity against a panel of human cancer cell lines (Hep- G 2, MG-63, and MCF-7). The cells were dosed with these Schiff bases at varying concentrations, and cell viability was measured by a 3-(4, 5-dimethylthiazol-2-yl)-2, 5- diphenyltetrazolium bromide (MTT) assay. Significant anticancer activities were observed ...