Antitrichomonal activity of mesoionic thiazolo [3, 2-a] pyridines

…, EB Sjogren, TR Matthews

文献索引：Walker, Keith A. M.; Sjogren, Eric B.; Matthews, Thomas R. Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1673 - 1679

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被引用次数: 6

摘要

Scheme I related compounds4 have shown that the remarkable specificity toward anaerobes (and facultative anaerobes) is due to the higher reduction potentials occurring in these cells relative to aerobic (eg, mammalian) cells. In susceptible cells, reduction of metronidazole establishes a concentration gradient6p7 favoring further diffusion into these cells, with the accumulation of reduction products. It has been shown that, during the ...