Peptidyl aldehyde inhibitors of calpain incorporating P 2-proline mimetics

…, R Korukonda, TL Huang, L LeCour

文献索引：Donkor, Isaac O.; Korukonda, Rajani; Huang, Tien L.; LeCour Jr., Louis Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 5 p. 783 - 784

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被引用次数: 22

摘要

Four new peptidyl aldehydes bearing proline mimetics at the P2-position were synthesized and studied as inhibitors of calpain I, cathepsin B, and selected serine proteases. The ring size of the P2-constraining residue influenced the inhibitory potency and selectivity of the compounds for calpain I compared to the other proteases.