Tetrahedron Letters

Ruthenium tetroxide oxidation of cyclic N-acylamines by a single layer method: formation of ω-amino acids

M Kaname, S Yoshifuji, H Sashida

文献索引：Kaname, Mamoru; Yoshifuji, Shigeyuki; Sashida, Haruki Tetrahedron Letters, 2008 , vol. 49, # 17 p. 2786 - 2788

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被引用次数: 6

摘要

The ruthenium tetroxide oxidation of cyclic N-acyl amines by a 10% NaIO4 aqueous solution containing tert-butanol as a single layer system resulted in the endo-cyclic C–N bond cleavage to afford the ω-amino acids as almost sole products in good yields, while a similar oxidation under the double layer using a NaIO4 aqueous solution, and ethyl acetate gave the N-acyl lactams.