Tetrahedron

ortho-Induced transition-metal-free C-arylation cyclization reaction for the synthesis of polysubstituted isocoumarins

L Liu, J Hu, XC Wang, MJ Zhong, XY Liu, SD Yang…

文献索引：Liu, Lei; Hu, Jie; Wang, Xiang-Chuan; Zhong, Mei-Jin; Liu, Xue-Yuan; Yang, Shang-Dong; Liang, Yong-Min Tetrahedron, 2012 , vol. 68, # 27-28 p. 5391 - 5395

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被引用次数: 12

摘要

A new protocol for the synthesis of polysubstituted isocoumarins from 2-iodobenzoic acid and β-diketone compounds has been developed. The occurrence of C-arylation cyclization reaction in transition-metal-free systems and ortho-induced substrates has been exploited. Reactions using these inexpensive conditions have displayed high functional group tolerance and excellent yields.

~69%

29539-21-7

3-甲基异色烯-1-酮

~70%

~58%

~86%

~88%

~14%

~83%

~80%

~78%

~37%

~75%

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