The Journal of Organic Chemistry

Preparation of (R)-phenylalanine analogs by enantioselective destruction using L-amino acid oxidase

MC Pirrung, N Krishnamurthy

文献索引：Pirrung, Michael C.; Krishnamurthy, N. Journal of Organic Chemistry, 1993 , vol. 58, # 4 p. 957 - 958

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被引用次数: 15

摘要

Because of the potent biological activities of naturallyoccurring amino acids and peptides and the desire for the development of therapeutics based on natural leads, methoda for preparation of unnatural amino acids have acquired great importance in medicinal chemistry.'Several of these methods are aimed specifically at the (R)-enantioniem; e acccBB to such substances provides an avenue to overcome endogenous proteolytic degradation ...