Organic letters

Synthesis of Novel Angular Spirocyclic Azetidines

C Guérot, BH Tchitchanov, H Knust, EM Carreira

文献索引：Guerot, Carine; Tchitchanov, Boris H.; Knust, Henner; Carreira, Erick M. Organic Letters, 2011 , vol. 13, # 4 p. 780 - 783

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被引用次数: 26

摘要

The syntheses of a variety of novel angular azaspiro [3.3] heptanes are reported. gem- Difluoro and gem-dimethyl variants of the angular 1, 6-diazaspiro [3.3] heptane module were prepared in high yields using efficient sequences. Additionally, a practical one-pot synthesis of 5-oxo-2-azaspiro [3.3] heptanes and subsequent conversions into functionalized derivatives are described. The methods reported are amenable to the synthesis of these ...