Intermediates in the Paal-Knorr synthesis of pyrroles

…, K Amarnath, WM Valentine, LA Wetterau…

文献索引：Amarnath, Venkataraman; Anthony, Douglas C.; Amarnath, Kalyani; Valentine, William M.; Wetterau, Lawrence A.; Graham, Doyle G. Journal of Organic Chemistry, 1991 , vol. 56, # 24 p. 6924 - 6931

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被引用次数: 113

摘要

Introduction A pyrrole ring is part of many important biological compounds.'The condensation of 1, Cdicarbonyl compounds with primary amines constitutes a very useful method for generating pyrroles. This reaction, known as the Paal-Knorr~ ondensation, 2*~ is applicable to a wide variety of y-dicarbonyl compounds and primary amines. In spite of its synthetic utility, the mechanism of the Paal-Knorr reaction is still not completely ...