Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers

E Martini, C Ghelardini, S Dei, L Guandalini…

文献索引：Martini, Elisabetta; Ghelardini, Carla; Dei, Silvia; Guandalini, Luca; Manetti, Dina; Melchiorre, Michele; Norcini, Monica; Scapecchi, Serena; Teodori, Elisabetta; Romanelli, Maria Novella Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 3 p. 1431 - 1443

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被引用次数: 12

摘要

A series of 2-oxopiperazine, 4-aminomethyl-, 3-amino-and 3-aminomethylpiperidine analogues of DM235 (sunifiram) and MN19 (sapunifiram), two previously reported potent cognition-enhancers, have been synthesized and tested in the mouse passive-avoidance test. The compounds display minimal effective doses in the range 0.3–10mg/kg. Although the new substances do not show improved activity when compared to the parent ...