Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter

…, D Parrish, JR Deschamps, A Janowsky

文献索引：Froimowitz, Mark; Gu, Yonghong; Dakin, Les A.; Nagafuji, Pamela M.; Kelley, Charles J.; Parrish, Damon; Deschamps, Jeffrey R.; Janowsky, Aaron Journal of Medicinal Chemistry, 2007 , vol. 50, # 2 p. 219 - 232

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被引用次数: 25

摘要

Methylphenidate analogues, in which the carbomethoxy has been replaced by an alkyl group and with different phenyl substituents, have been synthesized and tested in monoamine transporter assays. As predicted from a pharmacophore model, most of the RR/SS diastereomers showed high potency as dopamine reuptake inhibitors. Analogues with a 4-chlorophenyl group and an unbranched initial alkyl atom had consistently ...