The synthesized novel fluorinated compound (LJJ-10) induces death receptor-and mitochondria-dependent apoptotic cell death in the human osteogenic sarcoma U- …

MJ Hour, JS Yang, TL Chen, KT Chen, SC Kuo…

文献索引：Hour, Mann-Jen; Yang, Jai-Sing; Chen, Tai-Lin; Chen, Kuan-Tin; Kuo, Sheng-Chu; Chung, Jing-Gung; Lu, Chi-Cheng; Chen, Chia-Yi; Chuang, Yi-Hsuan European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 2709 - 2721

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被引用次数: 8

摘要

Abstract We designed the 6-fluoro-2-(3-fluorophenyl)-4-substituted anilinoquinazoline derivatives as less toxic anti-cancer candidates. Our result demonstrated that LJJ-10 has greater cytotoxicity than that of the other compounds in human osteogenic sarcoma U-2 OS cells. LJJ-10-induced apoptosis was associated with enhancing ROS generation, DNA damage, and an increase of the protein levels of Fas, FasL, FADD, caspase-8, cytochrome ...