Practical preparation and resolution of 1-(2'-diphenylphosphino-1'-naphthyl) isoquinoline: A useful ligand for catalytic asymmetric synthesis

CW Lim, O Tissot, A Mattison, MW Hooper…

文献索引：Lim, Chung Woo; Tissot, Olivier; Mattison, Andrew; Hooper, Mark W.; Brown, John M.; Cowley, Andrew R.; Hulmes, David I.; Blacker, A. John Organic Process Research and Development, 2003 , vol. 7, # 3 p. 379 - 384

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被引用次数: 91

摘要

A practical synthesis of the atropisomerically chiral ligand QUINAP is described, followed by its efficient resolution into enantiomers by employing a deficiency of the chloropalladium complex derived from 1'-(R)-1'-(dimethylamino)-1-ethylnaphthalene. The X-ray structure of the ligand, which crystallises as a conglomerate, is reported.