European journal of organic chemistry

Synthesis of New Water??Soluble DNA??Binding Subunits for Analogues of the Cytotoxic Antibiotic CC??1065 and Their Prodrugs

LF Tietze, F Major

文献索引：Tietze, Lutz F.; Major, Felix European Journal of Organic Chemistry, 2006 , # 10 p. 2314 - 2321

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被引用次数: 27

摘要

Abstract Novel water-soluble indole-2-carboxylic acid derivatives (7, 13, 21 and 25) bearing a substituent with a tertiary amino functionality at C-5 have been prepared. These new DNA- binding subunits can be used for the synthesis of new analogues of the cytotoxic antibiotic CC-1065 and their corresponding prodrugs for antibody-directed enzyme prodrug therapy (ADEPT) within a selective treatment of cancer.(© Wiley-VCH Verlag GmbH & Co. KGaA, ...