Tetrahedron

N-benzhydryl-glycolamide esters (OBg esters) as carboxyl protecting groups in pept1de synthesis

M Amblard, M Rodriguez, J Martinez

文献索引：Amblard, Muriel; Rodriguez, Marc; Martinez, Jean Tetrahedron, 1988 , vol. 44, # 16 p. 5101 - 5108

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被引用次数: 24

摘要

N-Benzhydryl-glycolamide esters (OBg esters) of various N-protected amino acids have been synthesized. In order to demonstrate their usefulness in peptide chemistry, the syntheses of For-Met-Leu-Phe-OH (chemiotactic peptide) and Pro-Leu-Gly-NH2 (MIF) have been carried out. OBg esters are compatible with commonly used protecting groups and are cleanly and selectively removed in mild alkaline conditions without any side reaction, ...