Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from α-aminosuberic acid

P Kahnberg, AJ Lucke, MP Glenn…

文献索引：Kahnberg, Pia; Lucke, Andrew J.; Glenn, Matthew P.; Boyle, Glen M.; Tyndall, Joel D. A.; Parsons, Peter G.; Fairlie, David P. Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7611 - 7622

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被引用次数: 47

摘要

Chemotherapy in the last century was characterized by cytotoxic drugs that did not discriminate between cancerous and normal cell types and were consequently accompanied by toxic side effects that were often dose limiting. The ability of differentiating agents to selectively kill cancer cells or transform them to a nonproliferating or normal phenotype could lead to cell-and tissue-specific drugs without the side effects of current ...