Chemistry Letters

The First Enantiomerically Pure Synthesis of (S)-and (R)-Naftopidil Utilizing Hydrolytic Kinetic Resolution of (.+-.)-(. ALPHA.-Naphthyl) Glycidyl Ether

KK Kothakonda, DS Bose

文献索引：Kothakonda, Kiran Kumar; Bose, D. Subhas Chemistry Letters, 2004 , vol. 33, # 9 p. 1212 - 1213

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被引用次数: 8

摘要

Hydrolytic Kinetic Resolution (HKR) of (±)-(α-Naphthyl) glycidyl ether with (R, R)-salen Co (III) OAc complex provided enatiomerically pure (S)-naphthyl glycidyl ether and (R)-1- naphthyl glycerol; opening of the corresponding pure terminal epoxide with 1-(2- methoxyphenyl) piperizine gave the enantiomerically pure (S)-and (R)-Naftopidil.