Recognition of solvent exposed protein surfaces using anthracene derived receptors

…, J Hong, S Fletcher, AD Hamilton

文献索引：Wilson, Andrew J.; Hong, Jason; Fletcher, Steven; Hamilton, Andrew D. Organic and Biomolecular Chemistry, 2007 , vol. 5, # 2 p. 276 - 285

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被引用次数: 36

摘要

A new class of receptor is described that can selectively bind to the solvent exposed surface of proteins such as cytochrome c and lysozyme with low micromolar affinity over cytochrome c551, α-lactalbumin, myoglobin and RNase A, under physiologically relevant conditions (5 mM phosphate, pH 7.4). The use of anthracene as a hydrophobic scaffold allows the receptor to act as a selective chemosensor via fluorescence quenching or FRET. The ...