Journal of medicinal chemistry

Totally Synthetic Steroid Hormones. V. 1 (±)-2, 3-Dimethoxyestra-1, 3, 5 (10)-trien-17β-ol and Some Congeners

GH Douglas, CR Walk, H Smith

文献索引：Douglas,G.H. et al. Journal of Medicinal Chemistry, 1966 , vol. 9, p. 27 - 29

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被引用次数: 7

摘要

We2 have demonstrated the flexibility of our recently described tot'al syntheses of estrone3 by their extension to a variety of related 13P-alkylgonanes. This paper describes a further application to compounds of the (*)-2, 3-dimethoxyestra-l, 3, 5 (10)-triene series which were required for biological evaluation. The project seemed worthwhile in view of the occurrence of 2-methoxyestrone as a metabolite of estradiol in man. 4 The 6, 7-dimethoxy-l-tetralone ( ...