Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor

…, A Buschauer, S Elz, W Schunack, M Ruat…

文献索引：Hirschfeld; Buschauer; Elz; Schunack; Ruat; Traiffort; Schwartz Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2231 - 2238

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被引用次数: 43

摘要

The synthesis and biological evaluation of a new class of histamine Hz antagonists with N- cyano-N'-[~-[3-(1-piperidinylmethyl) phenoxy] alkyl] guanidine partial structure are described as part of an extensive research program to fmd model compounds for the development of new radioligands with high Hz affinity and specific activity. High receptor affinity is achieved by an additional (substituted) aromatic ring, which is connected with the third guanidine N ...