Tetrahedron Letters

Synthetic studies towards the 2-aminopyrimidine alkaloids variolins and meridianins from marine origin

PM Fresneda, P Molina, S Delgado, JA Bleda

文献索引：Fresneda, Pilar M.; Molina, Pedro; Delgado, Santiago; Bleda, Juan A. Tetrahedron Letters, 2000 , vol. 41, # 24 p. 4777 - 4780

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被引用次数: 66

摘要

A nine-step synthesis of 9-amino-4-methoxypyrido [3′, 2′: 4, 5] pyrrolo [1, 2-c] pyrimidine, a tricyclic ring system present in the marine alkaloids variolins is described. The natural marine products meridianins C–E have been synthetized for the first time starting from N- protected 3-acylindoles.