Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives

…, Y Wang, H Qian, Y Zhang, A Wellner, G Rubner…

文献索引：Liu, Wukun; Zhou, Jinpei; Bensdorf, Kerstin; Zhang, Huibin; Liu, Haoran; Wang, Yubin; Qian, Hai; Zhang, Yanchun; Wellner, Anja; Rubner, Gerhard; Huang, Wenlong; Guo, Cancheng; Gust, Ronald European Journal of Medicinal Chemistry, 2011 , vol. 46, # 3 p. 907 - 913

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被引用次数: 27

摘要

A series of C5-substituted licofelone ([2, 2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2, 3- dihydro-1H-pyrrolizin-5-yl] acetic acid) derivatives were developed by a parallel synthesis approach and investigated for cytotoxicity against MCF-7 and MDA-MB-231 cells as well as for anti-inflammatory potency in vitro and in vivo. Dependent on the C5-substituent, the compounds showed high selectivity for MCF-7 cells. Especially 2-oxoethyl benzoate ...