Nonpeptide GPIIb/IIIa inhibitors. 10. Centrally constrained alpha-sulfonamides are potent inhibitors of platelet aggregation

…, GD Hartman, RJ Gould, B Bednar, RA Bednar…

文献索引：Egbertson; Hartman; Gould; Bednar; Cook; Gaul; Holahan; Libby; Lynch Jr.; Lynch; Sitko; Stranieri; Vassallo Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 21 p. 2519 - 2524

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被引用次数: 29

摘要

Potency enhancing features of two series of fibrinogen receptor antagonists were combined to give analogs with improved potency and oral activity. Antagonists containing either alkyl or aryl sulfonamides and a central isoindolinone structural constraint demonstrate high affinity for both activated and unactivated platelet receptors.