Synthesis and cytotoxic evaluation of certain 4-anilino-2-phenylquinoline derivatives

YL Zhao, YL Chen, FS Chang, CC Tzeng

文献索引：Zhao, Yue-Ling; Chen, Yeh-Long; Chang, Feng-Shuo; Tzeng, Cherng-Chyi European Journal of Medicinal Chemistry, 2005 , vol. 40, # 8 p. 792 - 797

全文：HTML全文

被引用次数: 78

摘要

The present report describes the synthesis and cell growth inhibition of certain 4-anilino-2- phenylquinoline derivatives. 4-(4-Acetylphenylamino)-6-methoxy-2-phenylquinoline (11), its oxime 15a, and its methyloxime 15b, exhibited significant cytotoxicity against all 60 cancer cells with mean GI50 values of 3.89, 3.02, and 3.89 μM, respectively, while 4-(4- acetylanilino)-6-methoxy-2-phenylquinoline-3-carboxylic acid (9) and its 3-carboxylic acid ...