Reduction of Fluorinated Cyclopropene by Nitrogenase

F Ni, CC Lee, CS Hwang, Y Hu, MW Ribbe…

文献索引：Ni, Feng; Lee, Chi Chung; Hwang, Candy S.; Hu, Yilin; Ribbe, Markus W.; Mckenna, Charles E. Journal of the American Chemical Society, 2013 , vol. 135, # 28 p. 10346 - 10352

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被引用次数: 4

摘要

Reduction of the first known halogen-containing substrate by nitrogenase (N2ase), 3, 3- difluorocyclopropene (DFCP), was investigated. Reduction requires both N2ase proteins (MoFe and Fe protein), ATP, and an exogenous reductant (dithionite, DT), as with N2 and known alternative substrates of the enzyme. Two major products providing evidence for reductive C–F bond cleavage were confirmed, propene (P1, requiring 6e–/6H+) and 2- ...