A novel structural class of potent inhibitors of NF-κB activation: structure–activity relationships and biological effects of 6-aminoquinazoline derivatives
In this study, we have investigated the roles of substituents on the terminal phenyl ring at the C (4)-position of the quinazoline core to complete the structure–activity relationships (SARs) of our NF-κB activation inhibitors. Among them, compound 12j afforded highly potent inhibitory activity toward NF-κB transcriptional activation with IC50 value of 2nM, along with an excellent in vivo efficacy by reducing the edema formation seen in carrageenin- ...
![6-硝基-N-[2-[4-(戊氧基)苯基]乙基]-4-喹唑啉胺结构式](https://image.chemsrc.com/caspic/381/663597-19-1.png)
![N-[2-(4-bromophenyl)ethyl]-6-nitroquinazolin-4-amine结构式](https://image.chemsrc.com/caspic/481/647376-13-4.png)
![methyl 4-[2-[(6-nitroquinazolin-4-yl)amino]ethyl]benzoate结构式](https://image.chemsrc.com/caspic/405/647376-15-6.png)
![4-[2-[(6-nitroquinazolin-4-yl)amino]ethyl]benzoic acid结构式](https://image.chemsrc.com/caspic/329/647376-17-8.png)
![4-[2-[(6-nitroquinazolin-4-yl)amino]ethyl]benzamide结构式](https://image.chemsrc.com/caspic/243/647376-19-0.png)
![N,N-dimethyl-4-[2-[(6-nitroquinazolin-4-yl)amino]ethyl]benzamide结构式](https://image.chemsrc.com/caspic/350/647376-21-4.png)