As a part of our medicinal chemistry research program, we were interested in synthesizing N-(4-(2-aminopyridin-4-yl)thiazol-2-yl)-2-phenylacetamides 1. The synthesis of this class of compounds has not been previously reported to our knowledge. The most straightforward synthetic approach to introduce an amino group at the 2-position of pyridine is by thermal or microwave assisted reaction of benzylamines with 2-chloro or 2-fluoropyridines 2 to afford 3, 1 or by transition ...
