Radioiodination of new EGFR inhibitors as potential SPECT agents for molecular imaging of breast cancer

C Fernandes, C Oliveira, L Gano, A Bourkoula…

文献索引：Fernandes, Celia; Oliveira, Cristina; Gano, Lurdes; Bourkoula, Athanasia; Pirmettis, Ioannis; Santos, Isabel Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 12 p. 3974 - 3980

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被引用次数: 43

摘要

In our search for the development of novel SPECT radioligands for EGFR positive tumours, new potentially irreversible tyrosine kinase (TK) inhibitors are being explored. The radioiodination of N-{4-[(3-chloro-4-fluorophenyl) amino] quinazoline-6-yl}-3- bromopropionamide, a novel EGFR-TK inhibitor synthesised in our laboratory, was accomplished via halogen exchange. Purification by RP-HPLC gave [125I]-N-{4-[(3-chloro ...