Fused bicyclic derivatives of 2, 4-diaminopyrimidine as c-Met inhibitors

…, J Husten, JG Lisko, RJ McHugh, KL Milkiewicz…

文献索引：Weinberg, Linda R.; Albom, Mark S.; Angeles, Thelma S.; Husten, Jean; Lisko, Joseph G.; McHugh, Robert J.; Milkiewicz, Karen L.; Murthy, Seetha; Ott, Gregory R.; Theroff, Jay P.; Tripathy, Rabindranath; Underiner, Ted L.; Zificsak, Craig A.; Dorsey, Bruce D. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 164 - 167

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被引用次数: 13

摘要

The HGF-c-Met signaling axis is an important paracrine mediator of epithelial–mesenchymal cell interactions involving the regulation of multiple cellular activities including cell motility, mitogenesis, morphogenesis, and angiogenesis. Dysregulation of c-Met signaling (eg, overexpression or increased activation) is associated with the development of a wide range of tumor types; thus, inhibiting the HGF-c-Met pathway is predicted to lead to anti-tumor ...