Protein structure-based design, synthesis, and biological evaluation of 5-thia-2, 6-diamino-4 (3 H)-oxopyrimidines: Potent inhibitors of glycinamide ribonucleotide …

MD Varney, CL Palmer, WH Romines…

文献索引：Journal of Medicinal Chemistry, , vol. 40, # 16 p. 2502 - 2524

被引用次数: 42

摘要

... Journal of Medicinal Chemistry. ... Chemistry. Shown in Scheme 1 is the general strategy for the synthesis of the monocyclic 5-thiapyrimidinones 5−13. The key reaction in the sequence is the base-initiated coupling of ...

62224-19-5

5-溴噻吩-2-甲酸甲酯

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Synthesis and biological activity of acyclic analogs of 5, 1...

[Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1109 - 1116]