Tetrahedron letters

Efficient microwave-assisted synthesis of 1-(1H-indol-1-yl)-2-phenyl-3-(1H-1, 2, 4-triazol-1-yl) propan-2-ols as antifungal agents

…, F Giraud, T Corbin, YM Na, G Le Baut, P Marchand…

文献索引：Lebouvier, Nicolas; Giraud, Francis; Corbin, Typhanie; Na, Young Min; Le Baut, Guillaume; Marchand, Pascal; Le Borgne, Marc Tetrahedron Letters, 2006 , vol. 47, # 36 p. 6479 - 6483

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被引用次数: 31

摘要

New conazole antifungals, in the series of triazole alcohols 23a–d and 24a–e incorporating an indole moiety substituted at 5-position by halogens, a cyano or 4-methoxyphenyl group, have been synthesized by ring opening of corresponding oxiranes 15 and 16. These dihalogeno intermediates and their congeneers could be prepared in high yields by Corey– Chaykovsky reaction under microwave irradiation.