Anti-inflammatory/antiarthritic ketonic bisphosphonic acid esters

ST Schlachter, LA Galinet, SK Shields, DG Aspar…

文献索引：Schlachter, Stephen T.; Galinet, Louise A.; Shields, Sharon K.; Aspar, Danielle G.; Dunn, Colin J.; Staite, Nigel D.; Nugent, Richard A. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 9 p. 1093 - 1096

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被引用次数: 30

摘要

Bisphosphonate ester 2 is an inhibitor of inflammation, but is devoid of antiarthritic effects. SAR studies on a series of related bisphosphonate esters resulted in compounds 6e, 6i, 6j, and 6m, which exhibited excellent inhibition of an arthritis model, in addition to potent anti- inflammatory effects.