Tetrahedron letters

One-pot synthesis of 2-aminothiazoles using supported reagents

M Kodomari, T Aoyama, Y Suzuki

文献索引：Kodomari, Mitsuo; Aoyama, Tadashi; Suzuki, Yoshitada Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1717 - 1720

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被引用次数: 45

摘要

A simple and efficient method has been developed for the synthesis of 2-aminothiazoles from α-bromo ketones in one-pot using a supported reagents system, KSCN/SiO2– RNH3OAc/Al2O3, in which α-bromo ketone reacts first with KSCN/SiO2 and the product, α- thiocyano ketone, reacts with RNH3OAc/Al2O3 to give the final product, 2-aminothiazole, in high yield.