The current study describes the chemical synthesis of a series of (2-ethylbenzofuran-3- yl)(substituted-phenyl) methanone compounds and their subsequent in vitro testing via oocytes expressing hURAT1. The experimental data support the notion that a potent hURAT1 inhibitor requires an anion (ie, a formal negative charge) to interact with the positively charged hURAT1 binding pocket. An anion appears to be a primary requirement ...
