Tetrahedron

Isothiazoles. Part 14: New 3-aminosubstituted isothiazole dioxides and their mono-and dihalogeno derivatives

F Clerici, A Contini, ML Gelmi, D Pocar

文献索引：Clerici, Francesca; Contini, Alessandro; Gelmi, Maria Luisa; Pocar, Donato Tetrahedron, 2003 , vol. 59, # 47 p. 9399 - 9408

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被引用次数: 17

摘要

3-Alkylamino-and 3-arylamino isothiazole dioxides unsubstituted at C-4 and C-5 were synthesized starting from dithiopropionic amides. Taking advantage of the direct chlorination during the cyclization process or realizing an addition–elimination process with bromine on the final 3-aminoisothiazole dioxide derivatives, the corresponding 5-chloro-, 4, 5-dichloro- or the 4-bromoisothiazole dioxides could also be made available.